Lonicera hypoglauca inhibits xanthine oxidase and reduces 1 serum uric acid in mice
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چکیده
8 1 School of Chinese Medicine Resources, China Medical University, Taichung 404, 9 Taiwan 10 2 Department of Forestry, National Chung-Hsing University, Taichung 402, Taiwan 11 3 Graduate Institute of Biotechnology, Chaoyang University of Technology, Wufong, 12 Taichung 413, Taiwan 13 4 Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan 14 5 Tsuzuki Institute for Traditional Medicine, College of Pharmacy, China Medical 15 University, Taichung 404, Taiwan 16 6 Department of Chemistry, National Taiwan University, Taipei 106, Taiwan 17 7 Center for Food and Biomolecules, National Taiwan University, Taipei 106, Taiwan 18 19
منابع مشابه
Lonicera hypoglauca inhibits xanthine oxidase and reduces serum uric acid in mice.
Xanthine oxidase (XOD) catalyzes the oxidation of hypoxanthine to xanthine and then to uric acid, and is a key enzyme in the pathogenesis of hyperuricemia. The ability of extracts of Lonicera hypoglauca (Caprifoliaceae) to inhibit XOD was investigated in this study. An ethanol extract (LH-crude) of the leaves of L. hypoglauca and its derived EtOAc soluble sub-fractions (LH-EA) significantly inh...
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Although radon therapy is indicated for hyperuricemia, the underlying mechanisms of action have not yet been elucidated in detail. Therefore, we herein examined the inhibitory effects of radon inhalation and hot spring water drinking on potassium oxonate (PO)-induced hyperuricemia in mice. Mice inhaled radon at a concentration of 2000 Bq/m(3) for 24 h or were given hot spring water for 2 weeks....
متن کاملEssential oil from leaves of Cinnamomum osmophloeum acts as a xanthine oxidase inhibitor and reduces the serum uric acid levels in oxonate-induced mice.
The xanthine oxidase (XOD) inhibitory activity and anti-hyperuricemia effect in mice of Cinnamomum osmophloeum, which is an endemic tree in Taiwan, were evaluated in this study. The results demonstrated that the essential oil of C. osmophloeum leaves presented the strongest XOD inhibition activity (IC(50)=16.3 μg/ml); however, no significant XOD inhibition activities were found in ethanolic and...
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تاریخ انتشار 2010